Hello @edmaralino,
the recommended solution to this problem is to edit the ‘karamba.ini’ file which can be found in the installation folder of Karamba3D (accessible via double-click on the Karamba3D Desktop icon).
On startup of Grasshopper Karamba3D reads all settings from there. The ‘Settings’-component takes effect only after having been evaluated. If there are several loose ends of the directed graph which represents the Grasshopper definition, it is not defined which one of these gets executed first. So, in the first run of a definition it can happen that the ‘Settings’-component does not take effect before all other components.
–Clemens