The whole Ladybug+Honeybee plugin is consisted entirely of .ghuser objects. There is only a one compiled .gha file. We already had some issues with people running certain Ladybug+Honeybee .ghuser files on WIP versions of both Windows and Mac.
I do not know if this is related with WIP version specifically, or some part of it. Like using ironpython 2.7.5 instead of 2.7. Or using last Rhino 5 Grasshopper 0.9.0076 instead of WIP 1.0.0004. Or the newest ghpython component. Or using some Windows native classes. As you and Giulio explained recently, some of them can be related with a separate installation of ironpython. I do not know if all of them are caused by this.
The confusion may have been caused by my clumsy use of the term: “against”.
I should have used “for” instead. So it is guaranteed that all .ghuser files will be working for Rhino 5 Windows. There are no guarantees they will be working on WIP version (either Windows or Mac). At least not until Rhino 6 Windows is released.