.NET Framework 4.8 compability with Rhino 6

Hi all,

This maybe a silly question, but my Visual Studio 2022 informed me that.NET Framework 4.5 is no longer supported, even though we still have some plugins that use it. Will there be a compatibility issue with Rhino 6 if we upgrade to.NET Framework 4.8? Rhinocommon v6 on NuGet is still .NET Framework 4.5.