I am looking to find out if there is anyway to make a specific file enable/disable a plug in when initiated. For example I want whenever file “A” starts the 3D Connexion Mouse plug-in becomes disabled.
Not that I can think of.
You can disable a plug-in, then set it to be asked about loading it when Rhino starts, but that’s not linked to a specific 3DM file. It’s tied to how Rhino starts.
Check if this helps. It will be annoying for all documents you’ll see a popup asking if you want that plugin enabled, but I think it’s a good workaround for your issue.