Again, I apologize for the delay. Most plugins should automatically work with rhino.compute with two main caveats. The first is that a plugin will likely fail in compute if it utilizes a UI that requires some sort of input from a user. Remember, rhino.compute is a console application which runs Rhino and Grasshopper as a sub-process. It has no way to “click” a button or navigate a UI so if the plugin you want to run incorporates a user interface, then it will likely fail in rhino.compute. The second caveat is if a plugin makes wide use of the rhino document. Remember, rhino.compute runs in a headless environment. As such, there is no “document” that you can query for information. We have put a few utility methods to try to catch users who try to make a call to get access to the document tolerances (length and angle) and the document units. Hopefully, in those cases rhino.compute will receive a default value rather than crashing. But, if the plugin you’re trying to load has any other calls to a document, then it will likely fail as well.
I don’t know Ladybug very well so I don’t know how to advise you in that situation. Have you tried emailing Mostpha or posting a question in their forum?