Every instance of Rhino V8 WIP that gets started in Windows 10 re-toggles Lock Horizon in the 3DConnexion Space Mouse control panel.
I just discovered the pop-up menu you can get using the Rhino command SpaceMouse, and it too keeps defaulting back to Lock Horizon.
Ah! If I then save a new Rhino template file, it actually retains these settings. So Rhino has hidden settings. These should be in the Settings panel too then which currently defers to the 3DConnexion control panel.