In your example it appears you need to give the tool more faces to work with (increase target quad count) or increase Adaptive Size to focus the quads more in the areas of curvature since this hole is part of a much larger object or , as @BrianJ noted, provide guide curves to specify exactly where you want to influence vs spreading the distribution out evenly.
If the target quad count is too low, you will almost always have areas of detail that are sacrificed in order to meet the goal more closely.
Here you can see a smaller scale example of how the number of faces will produce different results.
If high curvature without regard for polycount is the intended desire then increasing Adaptive Size to 100% and enabling Adaptive Quad Count will allow the tool to focus all efforts on curvature and add additional polys where it wants.
If hard edges are acceptable, they can often reduce the polycount totals.