It’s a slow path to permanent breakage, but it gets there. Also, sometimes Rhino launches with popup toolbar already broken, but restarting fixes the issue.
I use popups a lot…like a lot, a lot. I try not to touch my KB when I model. I keep my left hand on the 3d navigator and my right on a Swiftpoint Z mouse. I use quick gestures on the mouse to pop-up context toolbars to execute commands.