This may apply to RH-70733 as well.
I have some popups tied to Ctrl + WASD. Using a ctrl+ shortcut seems to degrade PopUpToolbar gradually until it stops working.
Ctrl+S activates the popup at first → flashes the popup → have to press Ctrl+S twice to activate and stay → Ctrl+S fails will only flash the popup.
Continued attempts at using Ctrl+S completely breaks it, leaving no way to activate it until you restart.
options.ini with Ctrl+ KB shortcut settings
press ctrl+ shortcut twice to get a popup to stay
Work Fine With an Alias
options.ini with Alias settings
Alias works every time
Works Fine With Non-Ctrl Shortcuts
options.ini with F2 - F5 shortcuts
F2 F3 F4 F5 works every time