I posted a question about Rui files some time ago. They are limited in their use from the answers I got. I know my concern is with 3rd party plugins (TDM says it is a problem with Rhino) but it is along the same lines of wanting to be able to create and save a workspace. I loose my layout every time I have to restart Rhino.
I have ended up like Mitch…just learning to live with it.