It appears that InstantCAD is not directly applicable to Rhino since it uses parametric CAD

Based on the description in MIT News it sounds like InstantCAD is about optimizing a parametric model using analysis software, not about modeling. http://news.mit.edu/2017/reshaping-computer-aided-design-instantcad-0724 Its based on a new algorithm for interpolating between points in parameter space based on precomputed data which is claimed to allow real time feedback of analysis results as the parameters are changed.

*“It’s too data-intensive to compute every single point, so we have to come up with a way to predict any point in this space from just a small number of sampled data points,” says Schulz. “This is called ‘interpolation,’ and our key technical contribution is a new algorithm we developed to take these samples and estimate points in the space.”*

*“With this precomputed data, you can instantly improve and optimize the design in two ways. With “interactive exploration,” a user interface provides real-time feedback on how design changes will affect performance, like how the shape of a plane wing impacts air pressure distribution. With “automatic optimization,” you simply tell the system to give you a design with specific characteristics, like a drone that’s as lightweight as possible while still being able to carry the maximum amount of weight.”*