It appears that InstantCAD is not directly applicable to Rhino since it uses parametric CAD
Based on the description in MIT News it sounds like InstantCAD is about optimizing a parametric model using analysis software, not about modeling. http://news.mit.edu/2017/reshaping-computer-aided-design-instantcad-0724 Its based on a new algorithm for interpolating between points in parameter space based on precomputed data which is claimed to allow real time feedback of analysis results as the parameters are changed.
“It’s too data-intensive to compute every single point, so we have to come up with a way to predict any point in this space from just a small number of sampled data points,” says Schulz. “This is called ‘interpolation,’ and our key technical contribution is a new algorithm we developed to take these samples and estimate points in the space.”
“With this precomputed data, you can instantly improve and optimize the design in two ways. With “interactive exploration,” a user interface provides real-time feedback on how design changes will affect performance, like how the shape of a plane wing impacts air pressure distribution. With “automatic optimization,” you simply tell the system to give you a design with specific characteristics, like a drone that’s as lightweight as possible while still being able to carry the maximum amount of weight.”