How to detect an update/change of a number?

I guess the volume and/ or num of vertices of the mesh will never be identical to the previouse iteration of Millipede. The comparison of the Volume Mesh(current) with the previouse Mesh was just an idea of how to detect an geometry change and therefor to trigger Flexhopper again.

No not yet. But you’re right that needs to be done as well. Otherwise Octopus would start a 2nd iteration after the 1st Flexhopper Iteration. But Anemone has the option “Output after the last”. So there needs to be 2nd “outer” Anemone Loop with Flexhopper. What do you think?