Grasshopper Development Settings

I have a question about the development settings in grasshopper. I want to have two plugins in my grasshopper. However for the one “Memory load * .GHA assemblies using COFF byte arrays” need to be off while for the other one the need to be on. And otherwise, they are removed from my grasshopper.

Does someone know why this is? And can explain what the settings mean?
Kind regards,

You can change these settings in grasshopper ‘File>Preferences’ for each library independently.