I’ve found its not so much the mouse you use, but more the repetitious way you might use it.
It helps to become “ampimousterous” ie train yourself to use your non-dominant hand to also be able to use the mouse, and swap over regularly.
In my experience, it takes about a week to achieve reasonable accuracy with your other hand, and after that about a month or so to be able to swap back and forth without even without even thinking about it.
Consider learning to use a mouse is akin to leaning to draw with a brick, so no-one finds it intuitive when they are first learning to use one, regardless of which hand they use.
The input system I now use is a wacom pen (not just for rhino, but for everything) PLUS a mouse on the other side.
This gives me a lot of variety as to how I might choose to work, and I swap around a lot pretty much at random.
The other problem with a mouse is the buttons, and all that clicking, combined with the positional aspect at the same time.
Remember that the mouse click speed, scroll speed and so on can all be configured to how you might like them through standard windows 10 options.
If you are using a laptop, you might use the touchpad keys for the left and right clicks, while just using the mouse for positional needs. Its surprising how more free your hand will feel if you don’t have to configure it to continually be ready to click the keys.
Many years ago I made a “split mouse”. As the name implies, it was a mouse with no buttons, the buttons being on a remote little platform, with three keys (from a older style keyboard) arranged in a row, and wired to be left, middle and right click. This was placed on the opposite side of the keyboard from the mouse,
The mouse was encased in a paua shell, (which I selected from the local beach, where many differing sizes were washed up and half buried in the sand) which was an extremely pleasing shape to hold, and since there were no buttons, your hand just relaxed over it.
You might nowadays run a utility program that allows you to map any desired keyboard key to left / right or middle clicks…
Finally, it can also be helpful if using a wacom pen or other input device to move the cursor, to then immobilize the mouse by simply gaffer taping it to the desk, (or a small piece of plywood or similar). You place this where it is most comfortable to use; and then it is only used for the buttons.
Try it – it makes a big difference. If you don’t like it, you can just set it free from the tape, and if you do like it, then you might mod it by fixing it more permanently.
Sounds like a lot of hassle, but if you have to use a computer day to day, and your wrist or hand starts hurting, then it is well worth exploring alternatives.
Cheers
rabbit