I would try darwing the curve shape of the depression, pull curve to the bottle , split , offset and fillet edges
The handle: best cut the ends then finish the bottle body (without handle) then create desired handle and boolean union with the body
Trim the bottle and the offset with the shape curve from the side view,
This is the trick: Extrude the trimmed edge of the bottle inward normal to the surface (Fin command) 3 or 4 units.
FIlletSrf at say 3 units from the bottle to the fin surface.
FilletSrf from the first fillet to the offset surface.
This gets you fillets that are larger in radius than the depth of the depression and true rolling ball fillets all the way around - if that is needed,