I have found a video online https://vimeo.com/247048808 and they are talking about the calculation time of each language (C#, VB, Python). Python seems very slow. I believed, the calculation time between C# and Python is negligible. The test shows the difference.
However in terms of development, Python is still more comfortable and no need to be compiled. It works like a real time script. I think the best way for script creation is IronPython because when calculation time become crucial it is easier to turn IronPython into C# code.