C/C++ speed in Python? Yes, using Codon

What is Codon?

Codon is a high-performance Python compiler that compiles Python code to native machine code without any runtime overhead. Typical speedups over Python are on the order of 10-100x or more, on a single thread. Codon’s performance is typically on par with (and sometimes better than) that of C/C++. Unlike Python, Codon supports native multithreading, which can lead to speedups many times higher still.

My question: It is possible to use this compiler in Rhino and/or GHPython?

Not for IronPython, but it might work for CPython in Rhino. There is also numba for this at
https://numba.pydata.org/